描述
Deferiprone (DFP)去铁酮（铁螯合剂）
产品关键词：
Deferiprone (DFP)去铁酮；Liproxstatin-1；Iron chelator铁螯合剂；铁死亡抑制剂；BCP-T.A.；(1S,3R)-RSL3；Ferroptosis inducer铁死亡诱导剂；FeRhoNox-1 (Fe2+ indicator)亚铁离子荧光探针；C11 BODIPY 581/591；CAS：30652-11-0；
产品信息
|
产品名称 |
产品编号 | CAS NO. | 规格 | 价格（元） |
|
Deferiprone (DFP)去铁酮（铁螯合剂） |
MZ5276-100MG | 30652-11-0 | 100mg | 97 |
| Deferiprone (DFP)去铁酮（铁螯合剂） | MZ5276-1G | 30652-11-0 | 1g |
233 |
| Deferiprone (DFP)去铁酮（铁螯合剂） | MZ5276-5G | 30652-11-0 | 5g |
583 |
产品描述
去铁酮（Deferiprone, DFP）是一种铁螯合剂，按照3：1比例（配基：铁离子）与铁结合，具抗氧化剂和神经保护作用。DFP（100 µM）逆转HT-1080纤维肉瘤细胞内爱拉斯汀诱导的铁死亡，另外，DFP能降低原代大鼠肝细胞的胞内铁水平以及脂质过氧化，作用浓度分别是200 µM和50 µM。DFP（50mg/kg）能够减低兔海马内胆固醇饮食诱导的Aβ42和Aβ40增加，以及tau和GSK-3β磷酸化。
产品特性
| CAS NO：30652-11-0 | MDL NO：MFCD00134497 |
| 化学名：3-hydroxy-1,2-dimethyl-4(1H)-pyridinone | 同义名：CGP 37391、DN 18001AF |
| 分子式：C7H9NO2 | 分子量：139.15 |
| 外观：白色至类白色固体 | 纯度：≥98% |
| 溶解性：溶于甲醇（5mg/ml）、H2O（≥3mg/ml，需要超声或加热助溶） | |
化学结构式： |
|
保存与运输方法
保存：-20℃避光干燥保存，至少2年有效。
运输：冰袋运输。
注意事项
1） 针对溶解性比较差的化合物，可通过37℃孵育以及超声的方式来促进其溶解。
2） 本品并非商业化的临床药物，仅用作科研用途，不得用作临床诊断或治疗，不得用于食品或药品，绝对禁止用在人身上。
3） 为了您的安全和健康，请穿实验服并戴一次性手套操作。
储存液制备
 质量
浓度 |
1mg | 5mg | 10mg |
| 1mM | 7.1865 mL | 35.9324 mL | 71.8649 mL |
| 5mM | 1.4373 mL | 7.1865 mL | 14.3730 mL |
| 10mM | 0.7186 mL | 3.5932 mL | 7.1865 mL |
溶剂体积【温馨提示】：请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液置于-80°C保存，约6个月有效；-20°C保存，约1个月有效。溶液储存的过程中避免强光直射。
使用方法【源自文献，仅作参考】
| 文献1，Liu, R.-Z.; Zhang, S.; Zhang, W.; Zhao, X.-Y.; Du, G.-H. Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats. Antioxidants 2023, 12, 12. https://doi.org/10.3390/antiox12010012
体内研究（动物模型）： 动物模型（Animal Model）：Male SD rats 实验方法（Assay）：The rats were randomly divided into 5 groups: the control group, model group, BAI-300 group, BAI-150 group, and DFP-150 group. All of the groups received an intraperitoneal injection of 2.5 mg/kg rotenone q.d. for 6 weeks, except for the control group, which received an equal volume of vehicle. From the third week to the sixth week, the rats were administered 300 mg/kg of baicalein (BAI-300 group), 150 mg/kg baicalein (BAI-150 group), or 150 mg/kg of deferiprone (DFP-150 group) q.d. by gavage, while the control group and the model group received an equal volume of vehicle. The dose of baicalein was determined based on a previous study;the dose of deferiprone was based on its clinical trial (30 mg/kg/d) and preclinical studies. |
| 文献2，Fiorillo, M.; Tóth, F.; Brindisi, M.; Sotgia, F.; Lisanti, M.P. Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production. Cells 2020, 9, 1529. https://doi.org/10.3390/cells9061529
体外研究（细胞水平）： 细胞类型（Cell Type）：MCF7 cells 实验方法（Assay）：To evaluate the mitochondrial superoxide production, a MitoSOX probe was used.The MCF7 cells were treated with DFP (1 μM to 1000 μM) for 24 to 120 h. The vehicle alone (DMSO) control cells were processed in parallel.After 48 h, the cells were washed with PBS and incubated with MitoSOX (diluted in PBS/CM to a final concentration of 5 μM) for 10 min at 37 °C |
相关产品
| 货号 | 名称 | 规格 |
| MZ5271-5MG | Ferrostatin-1铁死亡抑制剂 | 5mg |
| MZ5272-5MG | Erastin铁死亡激活剂 | 5mg |
| MZ5273-10MG | (1S,3R)-RSL3 (GPx4 inhibitor)谷胱甘肽过氧化物酶4抑制剂 | 10mg |
| MZ5275-5MG | Liproxstatin-1铁死亡抑制剂 | 5mg |
| MX4558-50UG | FeRhoNox-1 (Fe2+ indicator)亚铁离子荧光探针 | 50μg |
| MX4559-24UG | FerroOrange (Fe2+ indicator)亚铁离子荧光探针 | 24μg |
| MX4580-50nmol | FerroFarRed (Fe2+ indicator)亚铁离子荧光探针 | 50nmol |
| MX5211-1MG | C11 BODIPY 581/591脂质过氧化荧光探针 | 1mg |
— —Written/Edited by V. Shallan【版权归集奇生物/MKBio懋康所有】