描述
Alenphosome™-A-阿仑膦酸酯 脂质体（阴离子）
技术指标
活性： 阿仑膦酸钠（CAS 121268-17-5），5.0 mg / mL
体积： 2.0毫升
脂质组成： 磷脂酰胆碱，磷脂酰甘油 和胆固醇
内部/外部溶液： 磷酸盐缓冲盐水（20mM的 磷酸钠 磷酸，09wt％NaCl）中，pH为7.0 – 7.5
使用方法：温热至室温，混合均匀后使用。
用法用量：他是一个新产品，并没有推荐剂量可在此点。请参阅以下文献以获取更多信息
参考文献
Benjamin J. Burwitz et al. Technical Advance: Liposomal alendronate depletes monocytes and macrophages in the nonhuman primate model of human disease. J Leukoc Biol. 2014 Sep; 96(3): 491–501. PMC4632165 (Link)
Renate Frei, Comparison of cytotoxic properties of free and liposomal bisphosphonates in vitro (Diploma Thesis) (Link)
Mönkkönen J, van Rooijen N, Ylitalo P., Effects of clodronate and pamidronate on splenic and hepatic phagocytic cells of mice. Pharmacol Toxicol. 1991 Apr;68(4):284-6. (Link)
Makkonen N, Hirvonen MR, Teräväinen T, Savolainen K, Mönkkönen J., Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro. J Pharmacol Exp Ther. 1996 May;277(2):1097-102 (link)
van Rooijen N, Kors N. Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations in the spleen. Calcif Tissue Int. 1989 Sep;45(3):153-6. (Link)